The Claddagh ring Irish: The design and customs associated with it originated in the Irish fishing village of the same name in Galway. The ring, as currently known, was first produced in the 17th century. The Claddagh ring belongs to...
Author contributions: Multiple sclerosis MS imposes substantial economic burdens on patients, their families, and society. Until now, there are few therapies available, but often unattractive parenteral application or severe side effects are serious issues. This study highlights the use of circular peptides as orally active T-cell-specific immunosuppressive therapeutics against the MS model experimental autoimmune encephalomyelitis, without inducing major adverse effects. Our work provides a proof of principle that nature-derived cyclic peptides serve as oral active therapeutics, utilizing their intrinsic bioactivity and stable three-dimensional structure.
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